Angela Brueggemann

Angela
Brueggemann
BSc St Olaf, MSc Iowa, DPhil Oxf
Fellow by Special Election in Biological Sciences
Associate Professor & Wellcome Trust Career Development Fellow

Teaching

I teach undergraduates on the Biology degree course and the Biomedical Sciences degree course in topics related to infectious diseases, molecular biology and genomics.

About me

I have been at Oxford since 2000 – initially for my DPhil, followed by a senior research fellowship and then a departmental lectureship, which brought me to St Catherine’s in 2006.  I am currently a research fellow funded by the Wellcome Trust in the Nuffield Department of Medicine.  My research group and I are based in the Peter Medawar Building for Pathogen Research.

Research

The main focus of my research is the pneumococcus, a bacterium that is a major cause of diseases such as otitis media, pneumonia and meningitis worldwide.  My current research involves using genomics to understand pneumococcal evolution, especially changes related to antimicrobial and vaccine selective pressures.

Graduate supervision

I supervise DPhil students and am happy to speak to prospective students.

Papers

Wyres KL, van Tonder, A, Lambertsen LM, Hakenbeck R, Parkhill J, Bentley SD, Brueggemann AB.Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974. BMC Genomics 2013; 14:500. [PMCID:PMC3726389]

Wyres KL, Lambertsen LM, Croucher NJ, McGee L, von Gottberg A, Linares J, Jacobs MR, Kristinsson KG, Beall BW, Klugman KP, Parkhill J, Hakenbeck R, Bentley SD, Brueggemann AB.Pneumococcal capsular switching: an historical perspective.J Infect Dis 2012; 207:439-49. [PMCID pending]

Wyres KL, Lambertsen LM, Croucher NJ, McGee L, von Gottberg A, Linares J, Jacobs MR, Kristinsson KG, Beall BW, Klugman KP, Parkhill J, Hakenbeck R, Bentley SD, Brueggemann AB.The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success.Genome Biol 2012;13:R103. [PMCID:PMC3580495]

Golubchik, T*/Brueggemann, AB*, Street, TL, Gertz, Jr, RE, Spencer, C, Ho, T, Giannoulatou, E, Link-Gelles, R, Harding, R, Beall, B, Peto, TEA, Moore, MR, Donnelly, P**, Crook, D**, Bowden, R**.Genomic sequencing for bacterial epidemiology: tracking a successful vaccine escape variant formed through a multi-fragment recombination event.Nature Genetics 2012;44:352–355; *co-first authors; **co-senior authors. [PMCID:PMC3303117]

Beall, BW, Gertz, Jr, RE, Whitney, CG, Moore, MR and Brueggemann, AB.The shifting genetic structure of invasive serotype 19A pneumococci in the United States.J Infect Dis 2011;203(10):1360-8. [PMCID:PMC3080895]